Does Grapefruit juice interact with ED pills like Cialis or Viagra. , Drinking such as Viagra or Cialis, can increase the levels of these medications in the body, which can worsen side effects such as headaches, hot flashes, or low blood pressure. This interaction occurs because grapefruit inhibits an enzyme called CYP3A4 in the digestive tract and liver, which normally breaks down these medications. While this interaction is not always dangerous, it can make the medication's effects less predictable. It is recommended to avoid grapefruit juice and other grapefruit products when taking ED medications, and to consult a healthcare professional if you have any questions.

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